Prologue - Our Science

OUR SCIENCE

Delving into the viral proteome

Viruses and the proteins they code for continually evolve for optimal engagement with their host’s biology, providing a treasure chest of potential medicines across many therapeutic areas. 

Found in Nature. Engineered by Evolution.

Proteins are powerful biological regulators, working together to control how our bodies function.

Proteins are powerful biological regulators, working together to control how our bodies function. Today, the viral proteome, the set of proteins produced across all viruses, contains more than 6 million proteins, dwarfing the 20,000 human proteins by orders of magnitude. This gap will continue to grow as sequencing efforts to identify novel viral genomes expand and viral proteins keep evolving against evolutionary pressures.

Using our Decoding Evolutionary Logic of Variant Ensembles (DELVE)™ Platform, we are the first to systematically harness the potential of the entire viral proteome to uncover proteins that can regulate human physiology and program them for the treatment of disease.

The DELVE Platform

Unlocking viral proteome-assisted drug discovery

DELVE is a scalable, cutting-edge platform that combines computation and high-throughput biology to identify powerful proteins with advanced characteristics.

At the heart of our platform is a comprehensive knowledge graph – the largest known database of viral protein structures layered with detailed data from known human proteins and annotations of previously uncharacterized viral proteins predicted through our proprietary computational framework. Through this knowledge graph, and with today’s advances in large language models and next-generation sequencing, we can identify associations between previously unexplored viral proteins and known human biology in order to identify powerful potential new medicines, and even unlock the association between viral proteins and common disease onset.

Discover

By unearthing the complex, multi-layered relationships between genes, proteins, and medicines, our knowledge graph generates new insights into disease mechanisms and treatment strategies. With these new insights, our novel computational algorithms systemically identify viral proteins and their unique features that may have desired impacts on human physiology.

Test

Once these new viral proteins have been identified, we characterize their function using our high-throughput and automated experimental platform which elucidates precisely how they interact with human physiology. We can select for candidates that exhibit unique molecular fingerprints with potential for differentiated therapeutic functions.

Design

By applying the rules of natural viral evolution, we can create novel therapeutic proteins, regardless of their homology to human proteins. The enhanced proteins can be programmed to have properties, some previously unique to viruses, that expand the functional boundaries of proteins encoded by our own genome.

Learn

The data from these validated proteins are fed back into our model, enabling it to improve in silico predictions and discover powerful potential new medicines faster than ever before.

Careers

Endless opportunities, revolutionary potential.

We are a trailblazing team dedicated to unraveling the mysteries and untapped potential of the viral proteome. Join us as we harness the power of evolution to create new medicines.